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Interactions médicamenteuses

Fluconazole + Siponimod

Gravité: Contre-indiquée

Fluconazole and Siponimod: contraindicated interaction.

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Résumé

Fluconazole inhibits both CYP2C9 and CYP3A4, the main pathways clearing siponimod, and can substantially raise siponimod exposure. This increases the risk of bradyarrhythmia, infections, liver injury and other dose-related effects.

Ce que signifie cette interaction, en termes simples

Fluconazole and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Fluconazole belongs to Anti Fungals; Siponimod belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Combined moderate inhibition of CYP2C9 and CYP3A4 by fluconazole reduces siponimod clearance.

Conduite à tenir

Do not coadminister; siponimod labeling advises against use with drugs that moderately inhibit both CYP2C9 and CYP3A4. Choose a different antifungal.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Fluconazole with Siponimod?

MediHelp rates the interaction as contraindicated. Fluconazole and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fluconazole inhibits both CYP2C9 and CYP3A4, the main pathways clearing siponimod, and can substantially raise siponimod exposure. This increases the risk of bradyarrhythmia, infections, liver injury and other dose-related effects.

How serious is the interaction between Fluconazole and Siponimod?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; siponimod labeling advises against use with drugs that moderately inhibit both CYP2C9 and CYP3A4. Choose a different antifungal.

What other medicines interact with Fluconazole?

MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.

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