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Interactions médicamenteuses

Siponimod + Thioridazine

Gravité: Contre-indiquée

Siponimod and Thioridazine: contraindicated interaction.

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Résumé

Siponimod can cause bradycardia and atrioventricular conduction delay at initiation, and thioridazine prolongs QTc. Bradycardia increases vulnerability to torsades de pointes. Siponimod labeling advises against use with QT-prolonging drugs. Thioridazine, a CYP2D6 substrate and inhibitor, is not expected to alter siponimod CYP2C9 metabolism meaningfully.

Ce que signifie cette interaction, en termes simples

Siponimod and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Siponimod belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Siponimod-induced heart rate slowing combined with thioridazine-induced QT prolongation increases torsades risk.

Conduite à tenir

Avoid the combination; use a different antipsychotic. If it cannot be avoided, obtain cardiology advice and ECG monitoring at initiation.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Siponimod with Thioridazine?

MediHelp rates the interaction as contraindicated. Siponimod and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Siponimod can cause bradycardia and atrioventricular conduction delay at initiation, and thioridazine prolongs QTc. Bradycardia increases vulnerability to torsades de pointes. Siponimod labeling advises against use with QT-prolonging drugs. Thioridazine, a CYP2D6 substrate and inhibitor, is not expected to alter siponimod CYP2C9 metabolism meaningfully.

How serious is the interaction between Siponimod and Thioridazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a different antipsychotic. If it cannot be avoided, obtain cardiology advice and ECG monitoring at initiation.

What other medicines interact with Thioridazine?

MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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