Drug interactions
Insulin degludec-insulin aspart + Megestrol
Severity: Moderate
Insulin degludec-insulin aspart and Megestrol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Megestrol has glucocorticoid-like activity and can cause hyperglycemia, worsening diabetes control and increasing insulin requirements. Effects are more evident at the higher doses used for appetite stimulation.
What this interaction means in plain words
Insulin degludec-insulin aspart and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Megestrol belongs to Oncology.
Why it happens
Progestogen with glucocorticoid activity that induces insulin resistance, opposing insulin action.
What to do
Monitor blood glucose regularly during megestrol therapy and increase the insulin dose as needed. Reduce the insulin dose again when megestrol is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin degludec-insulin aspart and Megestrol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Megestrol
- Dofetilide + Megestrol Contraindicated
- Insulin degludec / insulin aspart + Megestrol Moderate
- Insulin degludec-liraglutide + Megestrol Moderate
- Insulin degludec + Megestrol Moderate
- Insulin inhaled + Megestrol Moderate
- Mavacamten + Megestrol Moderate
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Megestrol?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Megestrol has glucocorticoid-like activity and can cause hyperglycemia, worsening diabetes control and increasing insulin requirements. Effects are more evident at the higher doses used for appetite stimulation.
How serious is the interaction between Insulin degludec-insulin aspart and Megestrol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly during megestrol therapy and increase the insulin dose as needed. Reduce the insulin dose again when megestrol is stopped.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
