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Interactions médicamenteuses

Insulin lispro + Rosiglitazone

Gravité: Majeure

Insulin lispro and Rosiglitazone: major interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Rosiglitazone improves insulin sensitivity and adds to insulin's glucose lowering, increasing hypoglycemia risk. Together they increase fluid retention, with a higher risk of edema, heart failure and possibly ischemic events.

Ce que signifie cette interaction, en termes simples

Insulin lispro and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Insulin lispro belongs to Endocrine; Rosiglitazone belongs to Endocrine.

Niveau de preuve: High

Pourquoi elle survient

Additive glucose lowering through insulin sensitization plus insulin, with PPAR-gamma-mediated fluid retention potentiated by insulin.

Conduite à tenir

Monitor for weight gain, edema and signs of heart failure, and lower the insulin dose if hypoglycemia occurs. Avoid in patients with symptomatic heart failure.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Insulin lispro with Rosiglitazone?

MediHelp rates the interaction as major. Insulin lispro and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rosiglitazone improves insulin sensitivity and adds to insulin's glucose lowering, increasing hypoglycemia risk. Together they increase fluid retention, with a higher risk of edema, heart failure and possibly ischemic events.

How serious is the interaction between Insulin lispro and Rosiglitazone?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for weight gain, edema and signs of heart failure, and lower the insulin dose if hypoglycemia occurs. Avoid in patients with symptomatic heart failure.

What other medicines interact with Insulin lispro?

MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.

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