Interactions médicamenteuses
Lamivudine + Sorbitol
Gravité: Modérée
Lamivudine and Sorbitol: moderate interaction.
Dernière mise à jour
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Résumé
Sorbitol-containing liquid medicines taken with lamivudine oral solution lower lamivudine exposure in a dose-related way. Reduced exposure may lead to inadequate viral suppression and resistance, especially in children.
Ce que signifie cette interaction, en termes simples
Lamivudine and Sorbitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lamivudine belongs to Anti Virals; Sorbitol belongs to Gastrointestinal Tract.
Pourquoi elle survient
Sorbitol appears to reduce lamivudine absorption, possibly through osmotic effects on the gut; the mechanism is not fully established.
Conduite à tenir
Avoid regular co-administration of sorbitol-containing solutions with lamivudine where possible. If unavoidable, monitor viral load closely or use lamivudine tablets or a sorbitol-free formulation.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Lamivudine
Autres interactions de Sorbitol
- Sodium polystyrene sulfonate + Sorbitol Majeure
- Deflazacort + Sorbitol Modérée
Questions fréquentes
Can I take Lamivudine with Sorbitol?
MediHelp rates the interaction as moderate. Lamivudine and Sorbitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorbitol-containing liquid medicines taken with lamivudine oral solution lower lamivudine exposure in a dose-related way. Reduced exposure may lead to inadequate viral suppression and resistance, especially in children.
How serious is the interaction between Lamivudine and Sorbitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular co-administration of sorbitol-containing solutions with lamivudine where possible. If unavoidable, monitor viral load closely or use lamivudine tablets or a sorbitol-free formulation.
What other medicines interact with Lamivudine?
MediHelp also lists interactions of Lamivudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Atidarsagene autotemcel, Betibeglogene autotemcel. The full list is on the Lamivudine page.
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