Interactions médicamenteuses
Sodium polystyrene sulfonate + Sorbitol
Gravité: Majeure
Sodium polystyrene sulfonate and Sorbitol: major interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Sorbitol given with sodium polystyrene sulfonate has been linked to intestinal necrosis, particularly in the colon, which can be fatal. The risk is greatest in postoperative, renal-impaired or constipated patients.
Ce que signifie cette interaction, en termes simples
Sodium polystyrene sulfonate and Sorbitol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sodium polystyrene sulfonate belongs to Miscellaneous; Sorbitol belongs to Gastrointestinal Tract.
Pourquoi elle survient
The mechanism is not established; hyperosmolar sorbitol effects on the bowel wall combined with resin are suspected.
Conduite à tenir
Avoid giving sorbitol with the resin, and use premixed sorbitol-containing products with caution. Use alternative potassium binders where appropriate and watch for abdominal pain, distension or GI bleeding.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
Autres interactions de Sorbitol
- Deflazacort + Sorbitol Modérée
- Lamivudine + Sorbitol Modérée
Autres interactions de Sodium polystyrene sulfonate
- Meloxicam + Sodium polystyrene sulfonate Majeure
- Calcium carbonate + Sodium polystyrene sulfonate Modérée
- Deflazacort + Sodium polystyrene sulfonate Modérée
- Levothyroxine + Sodium polystyrene sulfonate Modérée
- Lithium + Sodium polystyrene sulfonate Modérée
- Magnesium citrate + Sodium polystyrene sulfonate Modérée
Questions fréquentes
Can I take Sodium polystyrene sulfonate with Sorbitol?
MediHelp rates the interaction as major. Sodium polystyrene sulfonate and Sorbitol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sorbitol given with sodium polystyrene sulfonate has been linked to intestinal necrosis, particularly in the colon, which can be fatal. The risk is greatest in postoperative, renal-impaired or constipated patients.
How serious is the interaction between Sodium polystyrene sulfonate and Sorbitol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving sorbitol with the resin, and use premixed sorbitol-containing products with caution. Use alternative potassium binders where appropriate and watch for abdominal pain, distension or GI bleeding.
What other medicines interact with Sorbitol?
MediHelp also lists interactions of Sorbitol with, for example, Deflazacort, Lamivudine. The full list is on the Sorbitol page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
