Interactions médicamenteuses
Ledipasvir-sofosbuvir + Rifampin
Gravité: Contre-indiquée
Ledipasvir-sofosbuvir and Rifampin: contraindicated interaction.
Dernière mise à jour
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Résumé
Rifampin markedly induces P-glycoprotein and lowers sofosbuvir and ledipasvir exposure, which can compromise the antiviral response and cause treatment failure. The interaction is well recognized in labeling.
Ce que signifie cette interaction, en termes simples
Ledipasvir-sofosbuvir and Rifampin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Rifampin induces intestinal P-glycoprotein, reducing absorption and plasma concentrations of sofosbuvir and ledipasvir.
Conduite à tenir
Do not co-administer. Defer rifampin-containing therapy or select an alternative agent, or postpone hepatitis C treatment until rifampin is stopped.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contre-indiquée
- Ledipasvir-sofosbuvir + Phenobarbital Contre-indiquée
- Ledipasvir-sofosbuvir + Phenytoin Contre-indiquée
- Ledipasvir-sofosbuvir + Rifapentine Contre-indiquée
- Ledipasvir-sofosbuvir + St john's wort Contre-indiquée
- Ledipasvir-sofosbuvir + Tipranavir Contre-indiquée
Questions fréquentes
Can I take Ledipasvir-sofosbuvir with Rifampin?
MediHelp rates the interaction as contraindicated. Ledipasvir-sofosbuvir and Rifampin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifampin markedly induces P-glycoprotein and lowers sofosbuvir and ledipasvir exposure, which can compromise the antiviral response and cause treatment failure. The interaction is well recognized in labeling.
How serious is the interaction between Ledipasvir-sofosbuvir and Rifampin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Defer rifampin-containing therapy or select an alternative agent, or postpone hepatitis C treatment until rifampin is stopped.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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