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Interactions médicamenteuses

Ledipasvir-sofosbuvir + Phenytoin

Gravité: Contre-indiquée

Ledipasvir-sofosbuvir and Phenytoin: contraindicated interaction.

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Résumé

Phenytoin is an inducer of P-gp and CYP enzymes and is expected to substantially reduce ledipasvir and sofosbuvir exposure. This can cause failure of hepatitis C therapy. Labeling advises against use together.

Ce que signifie cette interaction, en termes simples

Ledipasvir-sofosbuvir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ledipasvir-sofosbuvir belongs to Anti Virals; Phenytoin belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Phenytoin induces P-glycoprotein and metabolic enzymes, reducing absorption and exposure of sofosbuvir and ledipasvir.

Conduite à tenir

Do not coadminister; replace phenytoin with a non-inducing antiepileptic before and during HCV treatment.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ledipasvir-sofosbuvir with Phenytoin?

MediHelp rates the interaction as contraindicated. Ledipasvir-sofosbuvir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin is an inducer of P-gp and CYP enzymes and is expected to substantially reduce ledipasvir and sofosbuvir exposure. This can cause failure of hepatitis C therapy. Labeling advises against use together.

How serious is the interaction between Ledipasvir-sofosbuvir and Phenytoin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; replace phenytoin with a non-inducing antiepileptic before and during HCV treatment.

What other medicines interact with Ledipasvir-sofosbuvir?

MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Rifampin. The full list is on the Ledipasvir-sofosbuvir page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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