Interactions médicamenteuses
Ledipasvir-sofosbuvir + St john's wort
Gravité: Contre-indiquée
Ledipasvir-sofosbuvir and St john's wort: contraindicated interaction.
Dernière mise à jour
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Résumé
St John's wort is a potent inducer of intestinal P-glycoprotein and can markedly lower plasma concentrations of both ledipasvir and sofosbuvir. Reduced exposure may lead to loss of antiviral activity, failure to achieve sustained virologic response and possible resistance.
Ce que signifie cette interaction, en termes simples
Ledipasvir-sofosbuvir and St john's wort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Induction of intestinal P-glycoprotein (and other inducible pathways) by St John's wort reduces absorption and plasma exposure of ledipasvir and sofosbuvir.
Conduite à tenir
Do not combine; stop St John's wort before starting the hepatitis C regimen and choose an alternative if a herbal antidepressant is desired. Counsel patients to avoid herbal products during treatment.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contre-indiquée
- Ledipasvir-sofosbuvir + Phenobarbital Contre-indiquée
- Ledipasvir-sofosbuvir + Phenytoin Contre-indiquée
- Ledipasvir-sofosbuvir + Rifampin Contre-indiquée
- Ledipasvir-sofosbuvir + Rifapentine Contre-indiquée
- Ledipasvir-sofosbuvir + Tipranavir Contre-indiquée
Questions fréquentes
Can I take Ledipasvir-sofosbuvir with St john's wort?
MediHelp rates the interaction as contraindicated. Ledipasvir-sofosbuvir and St john's wort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. St John's wort is a potent inducer of intestinal P-glycoprotein and can markedly lower plasma concentrations of both ledipasvir and sofosbuvir. Reduced exposure may lead to loss of antiviral activity, failure to achieve sustained virologic response and possible resistance.
How serious is the interaction between Ledipasvir-sofosbuvir and St john's wort?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop St John's wort before starting the hepatitis C regimen and choose an alternative if a herbal antidepressant is desired. Counsel patients to avoid herbal products during treatment.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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