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Interactions médicamenteuses

Ledipasvir-sofosbuvir + Tipranavir

Gravité: Contre-indiquée

Ledipasvir-sofosbuvir and Tipranavir: contraindicated interaction.

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Résumé

Tipranavir, given with ritonavir, induces P-glycoprotein and is expected to lower ledipasvir and sofosbuvir exposure considerably. This may compromise the antiviral response and lead to treatment failure.

Ce que signifie cette interaction, en termes simples

Ledipasvir-sofosbuvir and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ledipasvir-sofosbuvir belongs to Anti Virals; Tipranavir belongs to Anti Virals.

Niveau de preuve: Moderate

Pourquoi elle survient

Tipranavir/ritonavir induces intestinal P-glycoprotein, reducing absorption of ledipasvir and sofosbuvir.

Conduite à tenir

Avoid coadministration as labeled; use an alternative antiretroviral regimen or a different hepatitis C regimen in consultation with an HIV/HCV specialist.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ledipasvir-sofosbuvir with Tipranavir?

MediHelp rates the interaction as contraindicated. Ledipasvir-sofosbuvir and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tipranavir, given with ritonavir, induces P-glycoprotein and is expected to lower ledipasvir and sofosbuvir exposure considerably. This may compromise the antiviral response and lead to treatment failure.

How serious is the interaction between Ledipasvir-sofosbuvir and Tipranavir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration as labeled; use an alternative antiretroviral regimen or a different hepatitis C regimen in consultation with an HIV/HCV specialist.

What other medicines interact with Ledipasvir-sofosbuvir?

MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.

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