Interactions médicamenteuses
Lomitapide + Micafungin
Gravité: Modérée
Lomitapide and Micafungin: moderate interaction.
Dernière mise à jour
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Résumé
Lomitapide is highly dependent on CYP3A4 for clearance and its exposure rises markedly with inhibitors. Micafungin is only a weak inhibitor, so the effect is likely small, but increased lomitapide could worsen hepatotoxicity and gastrointestinal effects.
Ce que signifie cette interaction, en termes simples
Lomitapide and Micafungin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Micafungin belongs to Anti Fungals.
Pourquoi elle survient
Possible weak inhibition of CYP3A4-mediated lomitapide metabolism by micafungin.
Conduite à tenir
Monitor liver enzymes and tolerability; keep the lomitapide dose within labeled limits for use with weak CYP3A4 inhibitors.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Micafungin
- Micafungin + Saccharomyces boulardii Modérée
- Micafungin + Sirolimus Modérée
- Avapritinib + Micafungin Mineure
- Finerenone + Micafungin Mineure
- Isavuconazonium + Micafungin Mineure
- Ivacaftor + Micafungin Mineure
Autres interactions de Lomitapide
- Aprepitant + Lomitapide Contre-indiquée
- Clarithromycin + Lomitapide Contre-indiquée
- Crizotinib + Lomitapide Contre-indiquée
- Diltiazem + Lomitapide Contre-indiquée
- Efavirenz + Lomitapide Contre-indiquée
- Ensitrelvir + Lomitapide Contre-indiquée
Questions fréquentes
Can I take Lomitapide with Micafungin?
MediHelp rates the interaction as moderate. Lomitapide and Micafungin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is highly dependent on CYP3A4 for clearance and its exposure rises markedly with inhibitors. Micafungin is only a weak inhibitor, so the effect is likely small, but increased lomitapide could worsen hepatotoxicity and gastrointestinal effects.
How serious is the interaction between Lomitapide and Micafungin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and tolerability; keep the lomitapide dose within labeled limits for use with weak CYP3A4 inhibitors.
What other medicines interact with Micafungin?
MediHelp also lists interactions of Micafungin with, for example, Saccharomyces boulardii, Sirolimus, Avapritinib. The full list is on the Micafungin page.
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