Interactions médicamenteuses
Magnesium sulfate + Pancuronium
Gravité: Majeure
Magnesium sulfate and Pancuronium: major interaction.
Dernière mise à jour
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Résumé
Parenteral magnesium sulfate potentiates nondepolarizing neuromuscular blockers, giving a deeper and longer block. This can delay recovery and cause respiratory depression postoperatively.
Ce que signifie cette interaction, en termes simples
Magnesium sulfate and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Magnesium reduces presynaptic acetylcholine release and decreases postsynaptic sensitivity, adding to competitive blockade.
Conduite à tenir
Reduce the pancuronium dose and titrate to train-of-four monitoring, and keep ventilatory support available until full recovery is confirmed.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Pancuronium
- Amikacin + Pancuronium Majeure
- Bacitracin-neomycin-polymyxin + Pancuronium Majeure
- Capreomycin + Pancuronium Majeure
- Clindamycin + Pancuronium Majeure
- Colistin + Pancuronium Majeure
- Dexamethasone-tobramycin + Pancuronium Majeure
Questions fréquentes
Can I take Magnesium sulfate with Pancuronium?
MediHelp rates the interaction as major. Magnesium sulfate and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Parenteral magnesium sulfate potentiates nondepolarizing neuromuscular blockers, giving a deeper and longer block. This can delay recovery and cause respiratory depression postoperatively.
How serious is the interaction between Magnesium sulfate and Pancuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the pancuronium dose and titrate to train-of-four monitoring, and keep ventilatory support available until full recovery is confirmed.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
