Interactions médicamenteuses
Colistin + Pancuronium
Gravité: Majeure
Colistin and Pancuronium: major interaction.
Dernière mise à jour
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Résumé
Colistin (polymyxin E) has neuromuscular blocking effects and can markedly potentiate pancuronium. Prolonged paralysis and respiratory arrest are possible, and reversal with anticholinesterases or calcium may be incomplete.
Ce que signifie cette interaction, en termes simples
Colistin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colistin belongs to Anti Bacterial; Pancuronium belongs to Musculoskeletal.
Pourquoi elle survient
Additive neuromuscular blockade, as colistin inhibits presynaptic acetylcholine release and has postsynaptic effects.
Conduite à tenir
Avoid combined use where possible; if needed, reduce pancuronium dose and monitor with train-of-four. Ensure ventilatory support is available, especially in patients with renal impairment.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Pancuronium
- Amikacin + Pancuronium Majeure
- Bacitracin-neomycin-polymyxin + Pancuronium Majeure
- Capreomycin + Pancuronium Majeure
- Clindamycin + Pancuronium Majeure
- Dexamethasone-tobramycin + Pancuronium Majeure
- Gentamicin + Pancuronium Majeure
Autres interactions de Colistin
- Colistin + Polymyxin b Contre-indiquée
- Amikacin + Colistin Majeure
- Amphotericin b deoxycholate + Colistin Majeure
- Amphotericin b + Colistin Majeure
- Atracurium + Colistin Majeure
- Bacitracin + Colistin Majeure
Questions fréquentes
Can I take Colistin with Pancuronium?
MediHelp rates the interaction as major. Colistin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Colistin (polymyxin E) has neuromuscular blocking effects and can markedly potentiate pancuronium. Prolonged paralysis and respiratory arrest are possible, and reversal with anticholinesterases or calcium may be incomplete.
How serious is the interaction between Colistin and Pancuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible; if needed, reduce pancuronium dose and monitor with train-of-four. Ensure ventilatory support is available, especially in patients with renal impairment.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
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