Interactions médicamenteuses
Clindamycin + Pancuronium
Gravité: Majeure
Clindamycin and Pancuronium: major interaction.
Dernière mise à jour
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Résumé
Clindamycin can potentiate non-depolarising muscle relaxants such as pancuronium and prolong the blockade. Delayed recovery and respiratory depression have been reported, and the effect may not be fully reversed by anticholinesterases.
Ce que signifie cette interaction, en termes simples
Clindamycin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clindamycin belongs to Anti Bacterial; Pancuronium belongs to Musculoskeletal.
Pourquoi elle survient
Clindamycin has intrinsic neuromuscular blocking activity at pre- and postsynaptic sites that adds to pancuronium.
Conduite à tenir
Titrate pancuronium with train-of-four monitoring and keep ventilatory support available until recovery is complete. Consider an alternative antibiotic if feasible.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Pancuronium
- Amikacin + Pancuronium Majeure
- Bacitracin-neomycin-polymyxin + Pancuronium Majeure
- Capreomycin + Pancuronium Majeure
- Colistin + Pancuronium Majeure
- Dexamethasone-tobramycin + Pancuronium Majeure
- Gentamicin + Pancuronium Majeure
Autres interactions de Clindamycin
- Atracurium + Clindamycin Majeure
- Cisatracurium + Clindamycin Majeure
- Clindamycin + Microbiota Majeure
- Clindamycin + Rapacuronium Majeure
- Clindamycin + Rocuronium Majeure
- Clindamycin + Vecuronium Majeure
Questions fréquentes
Can I take Clindamycin with Pancuronium?
MediHelp rates the interaction as major. Clindamycin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clindamycin can potentiate non-depolarising muscle relaxants such as pancuronium and prolong the blockade. Delayed recovery and respiratory depression have been reported, and the effect may not be fully reversed by anticholinesterases.
How serious is the interaction between Clindamycin and Pancuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate pancuronium with train-of-four monitoring and keep ventilatory support available until recovery is complete. Consider an alternative antibiotic if feasible.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
