Interactions médicamenteuses
Amikacin + Pancuronium
Gravité: Majeure
Amikacin and Pancuronium: major interaction.
Dernière mise à jour
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Résumé
Amikacin has neuromuscular blocking activity and can intensify and prolong pancuronium-induced paralysis. This may lead to delayed recovery, residual weakness and respiratory depression or apnea.
Ce que signifie cette interaction, en termes simples
Amikacin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amikacin belongs to Anti Bacterial; Pancuronium belongs to Musculoskeletal.
Pourquoi elle survient
Additive neuromuscular blockade through reduced presynaptic acetylcholine release and postsynaptic receptor blockade.
Conduite à tenir
Monitor neuromuscular function with train-of-four and reduce pancuronium dosing. Keep ventilatory support available until full recovery is confirmed.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Pancuronium
- Bacitracin-neomycin-polymyxin + Pancuronium Majeure
- Capreomycin + Pancuronium Majeure
- Clindamycin + Pancuronium Majeure
- Colistin + Pancuronium Majeure
- Dexamethasone-tobramycin + Pancuronium Majeure
- Gentamicin + Pancuronium Majeure
Autres interactions de Amikacin
- Amikacin + Cidofovir Contre-indiquée
- Adefovir + Amikacin Majeure
- Amikacin + Amphotericin b Majeure
- Amikacin + Amphotericin b deoxycholate Majeure
- Amikacin + Atracurium Majeure
- Amikacin + Bacitracin Majeure
Questions fréquentes
Can I take Amikacin with Pancuronium?
MediHelp rates the interaction as major. Amikacin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amikacin has neuromuscular blocking activity and can intensify and prolong pancuronium-induced paralysis. This may lead to delayed recovery, residual weakness and respiratory depression or apnea.
How serious is the interaction between Amikacin and Pancuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and reduce pancuronium dosing. Keep ventilatory support available until full recovery is confirmed.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Bacitracin-neomycin-polymyxin, Capreomycin, Clindamycin. The full list is on the Pancuronium page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
