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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Mavacamten + Omeprazole

Gravité: Contre-indiquée

Mavacamten and Omeprazole: contraindicated interaction.

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Résumé

Omeprazole inhibits CYP2C19 and can raise mavacamten exposure. Excess mavacamten can reduce left ventricular ejection fraction and cause heart failure from systolic dysfunction.

Ce que signifie cette interaction, en termes simples

Mavacamten and Omeprazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Mavacamten belongs to Cardiovascular; Omeprazole belongs to Gastrointestinal Tract.

Niveau de preuve: High

Pourquoi elle survient

Inhibition of CYP2C19-mediated metabolism of mavacamten increases its plasma concentrations.

Conduite à tenir

Avoid the combination; use an acid suppressant without CYP2C19 inhibition (e.g., an H2 blocker, or per labeling) if required. If started or stopped, follow label guidance with echocardiographic monitoring of ejection fraction.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Mavacamten with Omeprazole?

MediHelp rates the interaction as contraindicated. Mavacamten and Omeprazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Omeprazole inhibits CYP2C19 and can raise mavacamten exposure. Excess mavacamten can reduce left ventricular ejection fraction and cause heart failure from systolic dysfunction.

How serious is the interaction between Mavacamten and Omeprazole?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an acid suppressant without CYP2C19 inhibition (e.g., an H2 blocker, or per labeling) if required. If started or stopped, follow label guidance with echocardiographic monitoring of ejection fraction.

What other medicines interact with Omeprazole?

MediHelp also lists interactions of Omeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Omeprazole page.

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