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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Mercaptopurine + Ublituximab

Gravité: Majeure

Mercaptopurine and Ublituximab: major interaction.

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Résumé

Ublituximab depletes B cells, and mercaptopurine adds myelosuppressive and immunosuppressive effects. Together they can increase the risk of serious infections.

Ce que signifie cette interaction, en termes simples

Mercaptopurine and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Mercaptopurine belongs to Oncology; Ublituximab belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive immunosuppression from anti-CD20 B-cell depletion and purine antimetabolite lymphocyte and marrow suppression.

Conduite à tenir

Avoid combining where possible, or monitor closely for infection and check blood counts regularly. Consider the duration of effect of each drug when planning sequential therapy.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Mercaptopurine with Ublituximab?

MediHelp rates the interaction as major. Mercaptopurine and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ublituximab depletes B cells, and mercaptopurine adds myelosuppressive and immunosuppressive effects. Together they can increase the risk of serious infections.

How serious is the interaction between Mercaptopurine and Ublituximab?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or monitor closely for infection and check blood counts regularly. Consider the duration of effect of each drug when planning sequential therapy.

What other medicines interact with Mercaptopurine?

MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Azathioprine, Bcg vaccine live. The full list is on the Mercaptopurine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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