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Interactions médicamenteuses

Cyclosporin + Ublituximab

Gravité: Majeure

Cyclosporin and Ublituximab: major interaction.

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Résumé

Ublituximab depletes B cells and cyclosporine suppresses T cells, so together they raise the risk of serious infections. Effects of ublituximab persist for months after dosing.

Ce que signifie cette interaction, en termes simples

Cyclosporin and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cyclosporin belongs to Miscellaneous; Ublituximab belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive immunosuppression from anti-CD20 B-cell depletion and calcineurin inhibition.

Conduite à tenir

Avoid combining unless clearly needed; if used, monitor closely for infection and consider prophylaxis and the prolonged duration of B-cell depletion.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cyclosporin with Ublituximab?

MediHelp rates the interaction as major. Cyclosporin and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ublituximab depletes B cells and cyclosporine suppresses T cells, so together they raise the risk of serious infections. Effects of ublituximab persist for months after dosing.

How serious is the interaction between Cyclosporin and Ublituximab?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless clearly needed; if used, monitor closely for infection and consider prophylaxis and the prolonged duration of B-cell depletion.

What other medicines interact with Cyclosporin?

MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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