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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Leflunomide + Ublituximab

Gravité: Majeure

Leflunomide and Ublituximab: major interaction.

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Résumé

Both drugs suppress immune function, so combined use may increase the risk of serious infections. The risk is greater because leflunomide's active metabolite persists for a long time.

Ce que signifie cette interaction, en termes simples

Leflunomide and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Leflunomide belongs to Musculoskeletal; Ublituximab belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive immunosuppression from B-cell depletion by ublituximab and lymphocyte antiproliferation by leflunomide.

Conduite à tenir

Avoid combining where possible. If used together, monitor closely for infection, and consider the long persistence of teriflunomide, using accelerated elimination if needed.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Leflunomide with Ublituximab?

MediHelp rates the interaction as major. Leflunomide and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs suppress immune function, so combined use may increase the risk of serious infections. The risk is greater because leflunomide's active metabolite persists for a long time.

How serious is the interaction between Leflunomide and Ublituximab?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If used together, monitor closely for infection, and consider the long persistence of teriflunomide, using accelerated elimination if needed.

What other medicines interact with Leflunomide?

MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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