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Interactions médicamenteuses

Ozanimod + Phenelzine

Gravité: Contre-indiquée

Ozanimod and Phenelzine: contraindicated interaction.

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Résumé

Ozanimod has active metabolites that inhibit MAO-B, and concurrent nonselective MAO inhibition may lead to hypertensive crisis or serotonin syndrome. The interaction has not been formally studied, but labeling contraindicates the combination.

Ce que signifie cette interaction, en termes simples

Ozanimod and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ozanimod belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.

Niveau de preuve: Low

Pourquoi elle survient

Ozanimod's active metabolites inhibit MAO-B, which adds to nonselective MAO inhibition and may impair catecholamine and serotonin metabolism.

Conduite à tenir

Avoid concurrent use. Allow at least 14 days between stopping either drug and starting the other.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ozanimod with Phenelzine?

MediHelp rates the interaction as contraindicated. Ozanimod and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod has active metabolites that inhibit MAO-B, and concurrent nonselective MAO inhibition may lead to hypertensive crisis or serotonin syndrome. The interaction has not been formally studied, but labeling contraindicates the combination.

How serious is the interaction between Ozanimod and Phenelzine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. Allow at least 14 days between stopping either drug and starting the other.

What other medicines interact with Phenelzine?

MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.

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