Drug interactions
Ozanimod + Phenelzine
Severity: Contraindicated
Ozanimod and Phenelzine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod has active metabolites that inhibit MAO-B, and concurrent nonselective MAO inhibition may lead to hypertensive crisis or serotonin syndrome. The interaction has not been formally studied, but labeling contraindicates the combination.
What this interaction means in plain words
Ozanimod and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ozanimod belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Ozanimod's active metabolites inhibit MAO-B, which adds to nonselective MAO inhibition and may impair catecholamine and serotonin metabolism.
What to do
Avoid concurrent use. Allow at least 14 days between stopping either drug and starting the other.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
- Ozanimod + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ozanimod with Phenelzine?
MediHelp rates the interaction as contraindicated. Ozanimod and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod has active metabolites that inhibit MAO-B, and concurrent nonselective MAO inhibition may lead to hypertensive crisis or serotonin syndrome. The interaction has not been formally studied, but labeling contraindicates the combination.
How serious is the interaction between Ozanimod and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. Allow at least 14 days between stopping either drug and starting the other.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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