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Interactions médicamenteuses

Linezolid + Ozanimod

Gravité: Contre-indiquée

Linezolid and Ozanimod: contraindicated interaction.

Dernière mise à jour

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Résumé

Ozanimod active metabolites are formed through MAO-B and may inhibit MAO, and linezolid is an MAO inhibitor. The combination may cause hypertensive crisis or serotonergic toxicity.

Ce que signifie cette interaction, en termes simples

Linezolid and Ozanimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Linezolid belongs to Anti Bacterial; Ozanimod belongs to Central Nervous System.

Niveau de preuve: Low

Pourquoi elle survient

Additive MAO inhibition and altered ozanimod metabolite exposure.

Conduite à tenir

Avoid concurrent use and choose an alternative antibiotic. If unavoidable, monitor blood pressure and for serotonin toxicity.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Linezolid with Ozanimod?

MediHelp rates the interaction as contraindicated. Linezolid and Ozanimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod active metabolites are formed through MAO-B and may inhibit MAO, and linezolid is an MAO inhibitor. The combination may cause hypertensive crisis or serotonergic toxicity.

How serious is the interaction between Linezolid and Ozanimod?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose an alternative antibiotic. If unavoidable, monitor blood pressure and for serotonin toxicity.

What other medicines interact with Linezolid?

MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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