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Interactions médicamenteuses

Ozanimod + Tranylcypromine

Gravité: Contre-indiquée

Ozanimod and Tranylcypromine: contraindicated interaction.

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Résumé

Ozanimod's metabolism involves MAO-B, and its active metabolites may inhibit MAO. Combination with MAO inhibitors could cause hypertensive crisis or altered ozanimod exposure. Labeling contraindicates concurrent use.

Ce que signifie cette interaction, en termes simples

Ozanimod and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ozanimod belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.

Niveau de preuve: Low

Pourquoi elle survient

MAO inhibition alters ozanimod metabolite formation, and the metabolites may add MAO inhibition, risking adrenergic excess.

Conduite à tenir

Do not co-administer. Allow at least 14 days between stopping either drug and starting the other, per labeling.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ozanimod with Tranylcypromine?

MediHelp rates the interaction as contraindicated. Ozanimod and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod's metabolism involves MAO-B, and its active metabolites may inhibit MAO. Combination with MAO inhibitors could cause hypertensive crisis or altered ozanimod exposure. Labeling contraindicates concurrent use.

How serious is the interaction between Ozanimod and Tranylcypromine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Allow at least 14 days between stopping either drug and starting the other, per labeling.

What other medicines interact with Tranylcypromine?

MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.

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