Interactions médicamenteuses
Pretomanid + Propylthiouracil
Gravité: Majeure
Pretomanid and Propylthiouracil: major interaction.
Dernière mise à jour
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Résumé
Pretomanid-containing regimens are associated with hepatotoxicity, and propylthiouracil can also cause severe liver injury. Used together the risk of hepatic injury is increased.
Ce que signifie cette interaction, en termes simples
Pretomanid and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pretomanid belongs to Anti Bacterial; Propylthiouracil belongs to Endocrine.
Pourquoi elle survient
Additive hepatotoxicity.
Conduite à tenir
Avoid propylthiouracil in favor of an alternative antithyroid drug such as methimazole; if unavoidable, monitor liver function regularly and stop for significant elevations.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Propylthiouracil
Autres interactions de Pretomanid
- Amiodarone + Pretomanid Majeure
- Amobarbital + Pretomanid Majeure
- Amoxicillin-clavulanic acid + Pretomanid Majeure
- Apalutamide + Pretomanid Majeure
- Armodafinil + Pretomanid Majeure
- Azathioprine + Pretomanid Majeure
Questions fréquentes
Can I take Pretomanid with Propylthiouracil?
MediHelp rates the interaction as major. Pretomanid and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pretomanid-containing regimens are associated with hepatotoxicity, and propylthiouracil can also cause severe liver injury. Used together the risk of hepatic injury is increased.
How serious is the interaction between Pretomanid and Propylthiouracil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid propylthiouracil in favor of an alternative antithyroid drug such as methimazole; if unavoidable, monitor liver function regularly and stop for significant elevations.
What other medicines interact with Propylthiouracil?
MediHelp also lists interactions of Propylthiouracil with, for example, Carbamazepine, Clozapine, Methimazole. The full list is on the Propylthiouracil page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
