Interactions médicamenteuses
Propylthiouracil + Valoctocogene roxaparvovec
Gravité: Majeure
Propylthiouracil and Valoctocogene roxaparvovec: major interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Valoctocogene roxaparvovec commonly raises liver enzymes, and propylthiouracil is a known cause of serious liver injury. Combined use may increase hepatotoxicity risk and can complicate interpretation of enzyme rises after gene therapy.
Ce que signifie cette interaction, en termes simples
Propylthiouracil and Valoctocogene roxaparvovec can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Propylthiouracil belongs to Endocrine; Valoctocogene roxaparvovec belongs to Miscellaneous.
Pourquoi elle survient
Additive hepatotoxicity risk from propylthiouracil and gene therapy-related hepatocellular effects.
Conduite à tenir
Prefer an alternative antithyroid agent such as methimazole where possible. If used, monitor ALT and other liver tests frequently.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Propylthiouracil et Valoctocogene roxaparvovec, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres interactions de Propylthiouracil
- Carbamazepine + Propylthiouracil Majeure
- Clozapine + Propylthiouracil Majeure
- Methimazole + Propylthiouracil Majeure
- Pexidartinib + Propylthiouracil Majeure
- Pretomanid + Propylthiouracil Majeure
- Propylthiouracil + Sodium iodide i-131 Majeure
Autres interactions de Valoctocogene roxaparvovec
Questions fréquentes
Can I take Propylthiouracil with Valoctocogene roxaparvovec?
MediHelp rates the interaction as major. Propylthiouracil and Valoctocogene roxaparvovec can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valoctocogene roxaparvovec commonly raises liver enzymes, and propylthiouracil is a known cause of serious liver injury. Combined use may increase hepatotoxicity risk and can complicate interpretation of enzyme rises after gene therapy.
How serious is the interaction between Propylthiouracil and Valoctocogene roxaparvovec?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antithyroid agent such as methimazole where possible. If used, monitor ALT and other liver tests frequently.
What other medicines interact with Propylthiouracil?
MediHelp also lists interactions of Propylthiouracil with, for example, Carbamazepine, Clozapine, Methimazole. The full list is on the Propylthiouracil page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
