Riferimento farmaci
Avelumab
Avelumab is a medicine in the class oncology. It is used for renal cell carcinoma.
- Classe del farmaco: Oncology
- Indicato per: renal cell carcinoma
Ultimo aggiornamento Fonti: EMA SmPC
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
In breve
- Classe del farmaco
- Oncology
- Codice ATC
- L01FF04
- Forme farmaceutiche comuni
- iniezione
- Dosaggi comuni
- 20 mg/ml
- Interazioni note
- 5 (Moderata: 4 · Minore: 1)
- Nomi commerciali
- 3
- Paesi e mercati
- 3
Per cosa si usa
Come agisce
Human IgG1 monoclonal antibody against PD-L1. It blocks PD-L1 interaction with PD-1 and B7.1 receptors, removing suppression of cytotoxic CD8+ T-cells and restoring anti-tumour T-cell responses. It also induces NK cell-mediated tumour cell lysis via ADCC.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Monotherapy (MCC; first-line maintenance UC): 800 mg IV over 60 minutes every 2 weeks until disease progression or unacceptable toxicity
Gravidanza e allattamento
- Gravidanza
- Unsafe Limited data; based on mechanism it could cause foetal harm including abortion or stillbirth. Not recommended during pregnancy unless the woman's condition requires treatment.
- Allattamento
- Unsafe Unknown if excreted in human milk; advised not to breast-feed during treatment and for at least 1 month after the last dose.
Effetti indesiderati segnalati
- Fatigue
- Nausea
- Diarrhoea
- Constipation
- Decreased appetite
- Infusion-related reactions
Controindicazioni
- Hypersensitivity to the active substance or to any excipient
Chi deve prestare attenzione
- Infusion-related reactions can be severe; monitor for pyrexia, chills, flushing, hypotension, dyspnoea, wheezing, back pain, abdominal pain and urticaria.
- Immune-mediated adverse reactions (pneumonitis, hepatitis, colitis, pancreatitis, myocarditis, endocrinopathies, nephritis) may be severe or fatal; monitor, withhold and give corticosteroids according to severity.
- With axitinib, hepatotoxicity occurs with higher frequency of Grade 3 and 4 ALT/AST elevation; monitor liver function more frequently than with monotherapy.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (5)
- Avelumab + Cefadroxil Moderate
- Avelumab + Cefalexin Moderate
- Avelumab + Piperacillin Moderate
- Avelumab + Piperacillin-tazobactam Moderate
- Avelumab + Penicillin g Minor
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per aprire la monografia completa di Avelumab: dosi, gravidanza e allattamento, effetti indesiderati, avvertenze e tutte le interazioni.
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altri farmaci della stessa classe
Domande frequenti
What is Avelumab used for?
Avelumab is a medicine in the class oncology. It is used for Renal cell carcinoma.
What side effects have been reported with Avelumab?
Fatigue, Nausea, Diarrhoea, Constipation, Decreased appetite, Infusion-related reactions.
Can Avelumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Limited data; based on mechanism it could cause foetal harm including abortion or stillbirth. Not recommended during pregnancy unless the woman's condition requires treatment. Breastfeeding: Unsafe. Unknown if excreted in human milk; advised not to breast-feed during treatment and for at least 1 month after the last dose.
What does Avelumab interact with?
MediHelp lists 5 known interactions for Avelumab. Moderate: 4 · Minor: 1. The most serious include Cefadroxil, Cefalexin, Piperacillin.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
