Riferimento farmaci
Catumaxomab
Catumaxomab is a medicine in the class oncology.
- Classe del farmaco: Oncology
Ultimo aggiornamento Fonti: EMA SmPC
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In breve
- Classe del farmaco
- Oncology
- Codice ATC
- L01FX03
- Nomi commerciali
- 1
- Paesi e mercati
- 1
Come agisce
Trifunctional rat-mouse hybrid monoclonal antibody directed against EpCAM and CD3. A third binding site in the Fc region engages accessory immune cells via Fc-gamma receptors. This brings tumour cells, T-cells and accessory immune cells together and induces T-cell activation, T-cell killing, ADCC, CDC and phagocytosis.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Malignant ascites with EpCAM-positive carcinomas: four intraperitoneal infusions of 10 micrograms on day 0, 20 micrograms on day 3, 50 micrograms on day 7 and 150 micrograms on day 10; overall treatment period should not exceed 21 days
Gravidanza e allattamento
- Gravidanza
- Unknown No or limited human data, and animal studies are insufficient. EU label: not recommended in pregnancy or in women who could become pregnant and are not using contraception.
- Allattamento
- Unknown Unknown whether it passes into milk; a risk to the infant cannot be excluded. EU label: decide whether to stop breastfeeding or the therapy. Given into the abdomen for malignant ascites.
Effetti indesiderati segnalati
- Pyrexia
- Abdominal pain
- Nausea
- Vomiting
- Cytokine release syndrome
- Chills, fatigue, pain, diarrhoea, raised C-reactive protein
Controindicazioni
- Hypersensitivity to the active substance or to any of the excipients.
- Hypersensitivity to murine (rat and/or mouse) proteins.
Chi deve prestare attenzione
- Cytokine release symptoms can occur despite premedication, up to grade 4; patients should seek immediate medical attention.
- Systemic inflammatory response syndrome has been reported; patients should seek immediate medical attention if signs occur.
- Administration is not recommended in the presence of acute infections or other factors interfering with the immune system.
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Domande frequenti
What is Catumaxomab used for?
Catumaxomab is a medicine in the class oncology.
What side effects have been reported with Catumaxomab?
Pyrexia, Abdominal pain, Nausea, Vomiting, Cytokine release syndrome, Chills, fatigue, pain, diarrhoea, raised C-reactive protein.
Can Catumaxomab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No or limited human data, and animal studies are insufficient. EU label: not recommended in pregnancy or in women who could become pregnant and are not using contraception. Breastfeeding: Unknown. Unknown whether it passes into milk; a risk to the infant cannot be excluded. EU label: decide whether to stop breastfeeding or the therapy. Given into the abdomen for malignant ascites.
What does Catumaxomab interact with?
MediHelp does not list a checked interaction for Catumaxomab yet. Always tell your pharmacist about every medicine you take.
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