Riferimento farmaci
Caplacizumab
Caplacizumab is a medicine in the class cardiovascular. It is used for thrombocytopenic purpura.
- Classe del farmaco: Cardiovascular
- Indicato per: thrombocytopenic purpura
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Cardiovascular
- Dosaggi comuni
- 10 mg
- Interazioni note
- 19 (Maggiore: 17 · Moderata: 2)
- Nomi commerciali
- 2
- Paesi e mercati
- 2
Per cosa si usa
Come agisce
Targets the A1-domain of von Willebrand factor (vWF) and inhibits the interaction between vWF and platelets, reducing vWF-mediated platelet adhesion and platelet consumption.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
aTTP, first day: 11 mg bolus intravenous injection at least 15 minutes prior to plasma exchange, then 11 mg subcutaneous injection after completion of plasma exchange on day 1
Gravidanza e allattamento
- Gravidanza
- Unknown No human data. It raises bleeding risk, so mother and fetus or newborn may bleed, especially around delivery. Guinea pig studies showed no developmental harm. Use if needed for TTP; monitor mother and newborn for bleeding.
- Allattamento
- Unknown No milk data. LactMed: as a protein, milk levels are likely very low and it is probably digested in the infant gut; use with caution, especially with a newborn. Some advise not breastfeeding with acquired TTP. Weigh benefit.
Effetti indesiderati segnalati
- Epistaxis
- Headache
- Gingival bleeding
- Fatigue
- Urticaria
- Pyrexia
Controindicazioni
- Previous severe hypersensitivity reaction to caplacizumab-yhdp or any of the excipients.
Chi deve prestare attenzione
- Hemorrhage: serious and fatal bleeding can occur; risk increased with underlying coagulopathies or drugs affecting hemostasis. Interrupt if clinically significant bleeding occurs; von Willebrand factor concentrate may be given to correct hemostasis.
- Withhold for 7 days before elective surgery or invasive interventions; monitor closely for bleeding after resuming.
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Interazioni principali (19)
- Abciximab + Caplacizumab Major
- Acetylsalicylic acid + Caplacizumab Major
- Alteplase + Caplacizumab Major
- Anagrelide + Caplacizumab Major
- Apixaban + Caplacizumab Major
- Argatroban + Caplacizumab Major
- Caplacizumab + Clopidogrel Major
- Caplacizumab + Dabigatran etexilate Major
- Caplacizumab + Dalteparin Major
- Caplacizumab + Edoxaban Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Altri farmaci della stessa classe
Domande frequenti
What is Caplacizumab used for?
Caplacizumab is a medicine in the class cardiovascular. It is used for Thrombocytopenic purpura.
What side effects have been reported with Caplacizumab?
Epistaxis, Headache, Gingival bleeding, Fatigue, Urticaria, Pyrexia.
Can Caplacizumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data. It raises bleeding risk, so mother and fetus or newborn may bleed, especially around delivery. Guinea pig studies showed no developmental harm. Use if needed for TTP; monitor mother and newborn for bleeding. Breastfeeding: Unknown. No milk data. LactMed: as a protein, milk levels are likely very low and it is probably digested in the infant gut; use with caution, especially with a newborn. Some advise not breastfeeding with acquired TTP. Weigh benefit.
What does Caplacizumab interact with?
MediHelp lists 19 known interactions for Caplacizumab. Major: 17 · Moderate: 2. The most serious include Abciximab, Acetylsalicylic acid, Alteplase.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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