Riferimento farmaci
Ticagrelor
Ticagrelor is a medicine in the class cardiovascular. It is used for acute coronary syndrome.
- Classe del farmaco: Cardiovascular
- Indicato per: acute coronary syndrome
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In breve
- Classe del farmaco
- Cardiovascular
- Codice ATC
- B01AC24
- Forme farmaceutiche comuni
- compressa
- Dosaggi comuni
- 90 mg, 60 mg
- Interazioni note
- 166 (Controindicata: 3 · Maggiore: 80 · Moderata: 57 · Minore: 26)
- Nomi commerciali
- 15
- Paesi e mercati
- 6
Per cosa si usa
Come agisce
Ticagrelor and its major metabolite reversibly interact with the platelet P2Y12 ADP-receptor to prevent signal transduction and platelet activation, Ticagrelor and its active metabolite are approximately equipotent, Patients can be transitioned from clopidogrel to ticagrelor without interruption of antiplatelet effect
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Acute Coronary Syndrome or History of MI (Loading dose) (following ACS event): 180 mg PO x 1 dose
Gravidanza e allattamento
- Gravidanza
- Unknown Case reports have not shown a drug-related risk; in rats and rabbits it caused structural abnormalities at 5-7 times the human dose. UK label: not recommended in pregnancy; use contraception. If needed after a coronary stent, clopidogrel has more data; plan delivery around bleeding risk.
- Allattamento
- Unknown No human milk data; it reaches rat milk at higher levels than plasma. US label: not recommended; UK: decide whether to stop breastfeeding or the drug. LactMed: over 99% protein bound, so milk levels are likely low; prefer an alternative, especially for a newborn; watch for bruising.
Effetti indesiderati segnalati
- Diarrhea
- Nausea
- Dizziness
- Dyspnea
- Bleeding
- Ventricular pauses
Avvertenze in evidenza
- Bleeding risk Like other antiplatelet agents, can cause significant, sometimes fatal, bleeding Do not use with active pathological bleeding or a history of intracranial hemorrhage Do not start in patients planned to undergo urgent coronary artery bypass graft surgery (CABG); when possible, discontinue at least 5 days prior to any surgery Suspect bleeding in any patient who is hypotensive and has recently undergone coronary angiography, percutaneous coronary intervention (PCI), CABG, or other surgical procedures after starting ticagrelor If possible, manage bleeding without disc…
Controindicazioni
- History of intracranial hemorrhage (ICH)
- Active pathologic bleeding (eg, peptic ulcer, ICH)
Chi deve prestare attenzione
- Avoid use with severe hepatic impairment, which may increase ticagrelor serum levels
- Reported to cause false-negative results in platelet functional tests (eg, HIPA assay for HIT)
- Can cause ventricular pauses; bradyarrhythmias, including AV block reported
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (166)
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
- Acetylsalicylic acid + Ticagrelor Major
- Alteplase + Ticagrelor Major
- Apalutamide + Ticagrelor Major
- Aspirin + Ticagrelor Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Ticagrelor used for?
Ticagrelor is a medicine in the class cardiovascular. It is used for Acute coronary syndrome, Coronary artery disease, Myocardial infarction, Stroke, Transient ischemic attack.
What side effects have been reported with Ticagrelor?
Diarrhea, Nausea, Dizziness, Dyspnea, Bleeding, Ventricular pauses. Serious warning: Bleeding risk Like other antiplatelet agents, can cause significant, sometimes fatal, bleeding Do not use with active pathological bleeding or a history of intracranial hemorrhage Do not start in patients planned to undergo urgent coronary artery bypass graft surgery (CABG); when possible,…
Can Ticagrelor be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Case reports have not shown a drug-related risk; in rats and rabbits it caused structural abnormalities at 5-7 times the human dose. UK label: not recommended in pregnancy; use contraception. If needed after a coronary stent, clopidogrel has more data; plan delivery around bleeding risk. Breastfeeding: Unknown. No human milk data; it reaches rat milk at higher levels than plasma. US label: not recommended; UK: decide whether to stop breastfeeding or the drug. LactMed: over 99% protein bound, so milk levels are likely low; prefer an alternative, especially for a newborn; watch for bruising.
What does Ticagrelor interact with?
MediHelp lists 166 known interactions for Ticagrelor. Contraindicated: 3 · Major: 80 · Moderate: 57 · Minor: 26. The most serious include Itraconazole, Ketoconazole, Levoketoconazole.
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