Riferimento farmaci
Eptifibatide
Eptifibatide is a medicine in the class cardiovascular. It is used for acute coronary syndrome.
- Classe del farmaco: Cardiovascular
- Indicato per: acute coronary syndrome
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In breve
- Classe del farmaco
- Cardiovascular
- Codice ATC
- B01AC16
- Forme farmaceutiche comuni
- iniezione
- Dosaggi comuni
- 0.75 mg/ml, 2 mg/ml
- Interazioni note
- 42 (Maggiore: 21 · Moderata: 10 · Minore: 11)
- Nomi commerciali
- 3
- Paesi e mercati
- 2
Per cosa si usa
Come agisce
Blocks binding of fibrinogen and von Willebrand factor to glycoprotein IIb/IIIa receptor on platelet surface
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Acute Coronary Syndromes: 180 mcg/kg IV bolus over 1-2 min, THEN 2 mcg/kg/min IV continuous infusion; continue infusion until hospital discharge or initiation of coronary artery bypass graft surgery (CABG), up to 72 hours
Gravidanza e allattamento
- Gravidanza
- Unknown Published reports are too few to assess risk; untreated heart attack can be fatal to mother and fetus. Bleeding is the main risk, especially near delivery. EU label: do not use unless clearly necessary.
- Allattamento
- Unknown No milk data. A peptide likely destroyed in the infant gut. EU label: interrupt breastfeeding during treatment. LactMed: use with caution and watch the infant for bruising or bleeding. Given as a short IV course.
Effetti indesiderati segnalati
- Injection site reaction
- Thrombocytopenia
- Hypotension
- Bleeding
Controindicazioni
- History of internal bleeding, intracranial hemorrhage or neoplasm, CVA, thrombocytopenia
- AV malformation or aneurysm, aortic dissection, severe HTN, acute pericarditis
- Other parenteral glycoprotein IIb/IIIa inhibitors
Chi deve prestare attenzione
- In patients undergoing PCI, treatment may increase in major and minor bleeding at site of arterial sheath placement
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (42)
- Abrocitinib + Eptifibatide Major
- Acalabrutinib + Eptifibatide Major
- Acetylsalicylic acid + Eptifibatide Major
- Antithrombin alfa + Eptifibatide Major
- Antithrombin iii + Eptifibatide Major
- Apixaban + Eptifibatide Major
- Argatroban + Eptifibatide Major
- Betrixaban + Eptifibatide Major
- Bivalirudin + Eptifibatide Major
- Caplacizumab + Eptifibatide Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Altri farmaci della stessa classe
Domande frequenti
What is Eptifibatide used for?
Eptifibatide is a medicine in the class cardiovascular. It is used for Acute coronary syndrome, Percutaneous coronary intervention.
What side effects have been reported with Eptifibatide?
Injection site reaction, Thrombocytopenia, Hypotension, Bleeding.
Can Eptifibatide be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Published reports are too few to assess risk; untreated heart attack can be fatal to mother and fetus. Bleeding is the main risk, especially near delivery. EU label: do not use unless clearly necessary. Breastfeeding: Unknown. No milk data. A peptide likely destroyed in the infant gut. EU label: interrupt breastfeeding during treatment. LactMed: use with caution and watch the infant for bruising or bleeding. Given as a short IV course.
What does Eptifibatide interact with?
MediHelp lists 42 known interactions for Eptifibatide. Major: 21 · Moderate: 10 · Minor: 11. The most serious include Abrocitinib, Acalabrutinib, Acetylsalicylic acid.
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