Riferimento farmaci
Cobimetinib
Cobimetinib is a medicine in the class oncology. It is used for melanoma.
- Classe del farmaco: Oncology
- Indicato per: melanoma
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Oncology
- Codice ATC
- L01XE38
- Forme farmaceutiche comuni
- compressa
- Dosaggi comuni
- 20 mg
- Interazioni note
- 49 (Controindicata: 2 · Maggiore: 30 · Moderata: 10 · Minore: 7)
- Nomi commerciali
- 3
- Paesi e mercati
- 3
Per cosa si usa
Come agisce
Cobimetinib is a reversible inhibitor of MEK1 and MEK2, upstream regulators of the ERK pathway that promotes cellular proliferation.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Unresectable or metastatic melanoma with BRAF V600E or V600K mutation (with vemurafenib) and histiocytic neoplasms: 60 mg (three 20 mg tablets) orally once daily for the first 21 days of each 28-day cycle until disease progression or unacceptable toxicity
Gravidanza e allattamento
- Gravidanza
- Unsafe Can cause fetal harm: teratogenic and embryotoxic in rats at exposures similar to human doses; no human data. Avoid in pregnancy; use effective contraception during treatment and for 2 weeks after the last dose (US label; UK label: 3 months).
- Allattamento
- Unsafe No human milk data. Because of possible serious reactions in the infant, do not breastfeed during treatment and for 2 weeks after the last dose.
Effetti indesiderati segnalati
- Diarrhea
- Photosensitivity reaction
- Nausea
- Pyrexia
- Vomiting
Chi deve prestare attenzione
- New primary malignancies (cutaneous and non-cutaneous): monitor before, during and for up to 6 months after the last dose.
- Hemorrhage, including major hemorrhage, can occur; monitor for bleeding.
- Cardiomyopathy: evaluate LVEF before treatment, after one month, then every 3 months; safety not established with decreased LVEF.
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Interazioni principali (49)
- Cobimetinib + Efavirenz Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Amobarbital + Cobimetinib Major
- Apalutamide + Cobimetinib Major
- Aprepitant + Cobimetinib Major
- Bosentan + Cobimetinib Major
- Carbamazepine + Cobimetinib Major
- Chloramphenicol + Cobimetinib Major
- Ciprofloxacin + Cobimetinib Major
- Clarithromycin + Cobimetinib Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Cobimetinib used for?
Cobimetinib is a medicine in the class oncology. It is used for Melanoma.
What side effects have been reported with Cobimetinib?
Diarrhea, Photosensitivity reaction, Nausea, Pyrexia, Vomiting.
Can Cobimetinib be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: teratogenic and embryotoxic in rats at exposures similar to human doses; no human data. Avoid in pregnancy; use effective contraception during treatment and for 2 weeks after the last dose (US label; UK label: 3 months). Breastfeeding: Unsafe. No human milk data. Because of possible serious reactions in the infant, do not breastfeed during treatment and for 2 weeks after the last dose.
What does Cobimetinib interact with?
MediHelp lists 49 known interactions for Cobimetinib. Contraindicated: 2 · Major: 30 · Moderate: 10 · Minor: 7. The most serious include Efavirenz, Posaconazole, Amobarbital.
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