Interazioni tra farmaci
Cobimetinib + Posaconazole
Gravità: Controindicata
Cobimetinib and Posaconazole: contraindicated interaction.
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Sintesi
Posaconazole markedly raises cobimetinib exposure, increasing risks of hemorrhage, rhabdomyolysis, retinopathy, diarrhea and skin toxicity.
Cosa significa questa interazione in parole semplici
Cobimetinib and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobimetinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Perché avviene
Strong CYP3A4 inhibition reduces cobimetinib clearance.
Cosa fare
Avoid; use an antifungal or other therapy without strong CYP3A4 inhibition. If unavoidable, follow labeling for substantial cobimetinib dose reduction and monitor for toxicity.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Posaconazole
- Artemether + Posaconazole Controindicata
- Avanafil + Posaconazole Controindicata
- Conivaptan + Posaconazole Controindicata
- Dihydroergotamine intranasal + Posaconazole Controindicata
- Dihydroergotamine + Posaconazole Controindicata
- Dronedarone + Posaconazole Controindicata
Altre interazioni di Cobimetinib
- Cobimetinib + Efavirenz Controindicata
- Amobarbital + Cobimetinib Maggiore
- Apalutamide + Cobimetinib Maggiore
- Aprepitant + Cobimetinib Maggiore
- Bosentan + Cobimetinib Maggiore
- Carbamazepine + Cobimetinib Maggiore
Domande frequenti
Can I take Cobimetinib with Posaconazole?
MediHelp rates the interaction as contraindicated. Cobimetinib and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole markedly raises cobimetinib exposure, increasing risks of hemorrhage, rhabdomyolysis, retinopathy, diarrhea and skin toxicity.
How serious is the interaction between Cobimetinib and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; use an antifungal or other therapy without strong CYP3A4 inhibition. If unavoidable, follow labeling for substantial cobimetinib dose reduction and monitor for toxicity.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Conivaptan. The full list is on the Posaconazole page.
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