Interazioni tra farmaci
Clarithromycin + Cobimetinib
Gravità: Maggiore
Clarithromycin and Cobimetinib: major interaction.
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Sintesi
Clarithromycin, a strong CYP3A4 inhibitor, markedly increases cobimetinib exposure and may raise the risk of adverse effects such as hemorrhage, serous retinopathy, rhabdomyolysis, and cardiomyopathy.
Cosa significa questa interazione in parole semplici
Clarithromycin and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Cobimetinib belongs to Oncology.
Perché avviene
Clarithromycin inhibits CYP3A4-mediated metabolism of cobimetinib, greatly increasing its exposure.
Cosa fare
Avoid the combination and use a non-CYP3A4-inhibiting antibiotic such as azithromycin. If a strong inhibitor is short-term unavoidable, reduce cobimetinib dose per labeling and monitor closely.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Clarithromycin
- Astemizole + Clarithromycin Controindicata
- Avanafil + Clarithromycin Controindicata
- Cisapride + Clarithromycin Controindicata
- Clarithromycin + Colchicine Controindicata
- Clarithromycin + Conivaptan Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
Altre interazioni di Cobimetinib
- Cobimetinib + Efavirenz Controindicata
- Cobimetinib + Posaconazole Controindicata
- Amobarbital + Cobimetinib Maggiore
- Apalutamide + Cobimetinib Maggiore
- Aprepitant + Cobimetinib Maggiore
- Bosentan + Cobimetinib Maggiore
Domande frequenti
Can I take Clarithromycin with Cobimetinib?
MediHelp rates the interaction as major. Clarithromycin and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin, a strong CYP3A4 inhibitor, markedly increases cobimetinib exposure and may raise the risk of adverse effects such as hemorrhage, serous retinopathy, rhabdomyolysis, and cardiomyopathy.
How serious is the interaction between Clarithromycin and Cobimetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-CYP3A4-inhibiting antibiotic such as azithromycin. If a strong inhibitor is short-term unavoidable, reduce cobimetinib dose per labeling and monitor closely.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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