Riferimento farmaci
Liothyronine
Liothyronine is a medicine in the class endocrine. It is used for hypothyroidism.
- Classe del farmaco: Endocrine
- Indicato per: hypothyroidism
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Endocrine
- Forme farmaceutiche comuni
- compressa
- Interazioni note
- 53 (Moderata: 41 · Minore: 12)
- Nomi commerciali
- 2
- Paesi e mercati
- 1
Per cosa si usa
Come agisce
Thyroid hormones act by controlling DNA transcription and protein synthesis. T3 and T4 diffuse into the cell nucleus and bind to thyroid receptor proteins attached to DNA, activating gene transcription and messenger RNA synthesis.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Hypothyroidism: start 25 mcg orally once daily; increase by 25 mcg daily every 1 or 2 weeks if needed; usual maintenance 25 mcg to 75 mcg once daily
Gravidanza e allattamento
- Gravidanza
- Safe Post-marketing data have not shown more birth defects or miscarriage. Untreated hypothyroidism harms mother and fetus, so do not stop treatment: check TSH and adjust the dose during pregnancy. Levothyroxine is the usual first choice in pregnancy.
- Allattamento
- Safe Liothyronine (T3) is a normal component of milk; replacement doses are not a reason to stop breastfeeding (LactMed). US label: weigh benefits (insufficient data on infant effects). Levothyroxine is recommended for hypothyroidism while breastfeeding.
Effetti indesiderati segnalati
- Arrhythmias
- Headache
- Nervousness
- Insomnia
- Tremors
- Weight loss
Avvertenze in evidenza
- Not for treatment of obesity or for weight loss. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening toxicity, particularly with sympathomimetic amines.
Controindicazioni
- Uncorrected adrenal insufficiency
Chi deve prestare attenzione
- Cardiac adverse reactions in the elderly and patients with cardiovascular disease; start at lower doses
- Not for myxedema coma; use intravenous thyroid hormone products
- Acute adrenal crisis in adrenal insufficiency; give glucocorticoids first
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (53)
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
- Cholestyramine + Liothyronine Moderate
- Clomipramine + Liothyronine Moderate
- Colesevelam + Liothyronine Moderate
- Dapagliflozin-metformin + Liothyronine Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
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Altri farmaci della stessa classe
Domande frequenti
What is Liothyronine used for?
Liothyronine is a medicine in the class endocrine. It is used for Hypothyroidism, Thyroid cancer.
What side effects have been reported with Liothyronine?
Arrhythmias, Headache, Nervousness, Insomnia, Tremors, Weight loss. Serious warning: Not for treatment of obesity or for weight loss.
Can Liothyronine be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Post-marketing data have not shown more birth defects or miscarriage. Untreated hypothyroidism harms mother and fetus, so do not stop treatment: check TSH and adjust the dose during pregnancy. Levothyroxine is the usual first choice in pregnancy. Breastfeeding: Safe. Liothyronine (T3) is a normal component of milk; replacement doses are not a reason to stop breastfeeding (LactMed). US label: weigh benefits (insufficient data on infant effects). Levothyroxine is recommended for hypothyroidism while breastfeeding.
What does Liothyronine interact with?
MediHelp lists 53 known interactions for Liothyronine. Moderate: 41 · Minor: 12. The most serious include Alogliptin-metformin, Amitriptyline, Amobarbital.
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