Riferimento farmaci
Tiratricol
Tiratricol is a medicine in the class endocrine.
- Classe del farmaco: Endocrine
Ultimo aggiornamento Fonti: EMA SmPC
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In breve
- Classe del farmaco
- Endocrine
- Codice ATC
- H03AA04
- Interazioni note
- 13 (Maggiore: 1 · Moderata: 12)
- Nomi commerciali
- 1
- Paesi e mercati
- 1
Come agisce
Tiratricol is a naturally circulating metabolite of T3 that binds with high affinity to thyroid hormone receptors TRα and TRβ and has T3-like effects. It can enter MCT8-dependent cells without a functioning MCT8 transporter, so it can replace T3 in MCT8-dependent tissues.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Peripheral thyrotoxicosis in MCT8 deficiency, body weight 10 kg or above (adults, adolescents, children, infants): start 350 micrograms daily orally or via feeding tube in 1 to 3 doses; increase by 350 micrograms every two weeks to maintenance; target serum T3 below midpoint of normal range for age.
Gravidanza e allattamento
- Gravidanza
- Unsafe Contraindicated in pregnancy (EU): it crosses the placenta and animal studies showed reproductive toxicity. Women who could become pregnant must use effective contraception. Used for MCT8 deficiency, which almost only affects males.
- Allattamento
- Unknown Not known if it passes into milk; no LactMed record. EU label: risk cannot be excluded; decide whether to stop breastfeeding or the drug. e-lactancia: limited compatibility (a thyroid hormone analogue); prefer a safer option or stop breastfeeding.
Effetti indesiderati segnalati
- Hyperhidrosis
- Diarrhoea
- Irritability
- Anxiety
- Nightmares
Controindicazioni
- Hypersensitivity to the active substance or any excipient.
- Hyperthyroidism for reasons other than MCT8 deficiency (e.g. Graves' disease).
- Pregnancy.
Chi deve prestare attenzione
- Hypermetabolic signs and symptoms (hyperhidrosis, irritability, anxiety, insomnia, tachycardia, diarrhoea etc.) may occur at initiation or during titration; reduce dose if not resolved within 2 weeks.
- Use caution during titration in patients with cardiac disease.
- Tiratricol cross-reacts with T3 in immunoassays, giving unreliable results; LC/MS/MS is recommended.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (13)
- Levothyroxine + Tiratricol Major
- Calcium + Tiratricol Moderate
- Carbamazepine + Tiratricol Moderate
- Carbimazole + Tiratricol Moderate
- Charcoal + Tiratricol Moderate
- Chloroquine + Tiratricol Moderate
- Cholestyramine + Tiratricol Moderate
- Iron + Tiratricol Moderate
- Orlistat + Tiratricol Moderate
- Phenytoin + Tiratricol Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Altri farmaci della stessa classe
Domande frequenti
What is Tiratricol used for?
Tiratricol is a medicine in the class endocrine.
What side effects have been reported with Tiratricol?
Hyperhidrosis, Diarrhoea, Irritability, Anxiety, Nightmares.
Can Tiratricol be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated in pregnancy (EU): it crosses the placenta and animal studies showed reproductive toxicity. Women who could become pregnant must use effective contraception. Used for MCT8 deficiency, which almost only affects males. Breastfeeding: Unknown. Not known if it passes into milk; no LactMed record. EU label: risk cannot be excluded; decide whether to stop breastfeeding or the drug. e-lactancia: limited compatibility (a thyroid hormone analogue); prefer a safer option or stop breastfeeding.
What does Tiratricol interact with?
MediHelp lists 13 known interactions for Tiratricol. Major: 1 · Moderate: 12. The most serious include Levothyroxine, Calcium, Carbamazepine.
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