Riferimento farmaci
Tirofiban
Tirofiban is a medicine in the class cardiovascular. It is used for acute coronary syndrome.
- Classe del farmaco: Cardiovascular
- Indicato per: acute coronary syndrome
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In breve
- Classe del farmaco
- Cardiovascular
- Forme farmaceutiche comuni
- infusione, iniezione, soluzione
- Dosaggi comuni
- 12.5 mg/50 ml, 0.25 mg/ml, 12.5 mg
- Interazioni note
- 43 (Maggiore: 20 · Moderata: 13 · Minore: 10)
- Nomi commerciali
- 12
- Paesi e mercati
- 4
Per cosa si usa
Come agisce
Blocks binding of fibrinogen and von Willebrand factor to glycoprotein IIb/IIIa receptor on platelet surface; inhibits platelet aggregation
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Acute Coronary Syndrome: Loading dose: 25 mcg/kg IV infused within 5 min, THEN Post loading dose infusion: 0.15 mcg/kg/min IV for up to 18 hr
Gravidanza e allattamento
- Gravidanza
- Unknown Case reports have not linked it to birth defects or other harm; no fetal harm in rats or rabbits at higher doses. Untreated heart attack can be fatal to mother and fetus. Bleeding is the main risk, especially near delivery. Use if clearly needed.
- Allattamento
- Safe No human milk data; present in rat milk. Given IV and poorly absorbed orally, so the infant is unlikely to absorb meaningful amounts. LactMed: not a reason to stop breastfeeding; watch the infant for bruising or bleeding.
Effetti indesiderati segnalati
- Dizziness
- Bradycardia
- Bleeding
- Pelvic pain
- Coronary artery dissection
- Lower extremity pain
Chi deve prestare attenzione
- Concomitant use of fibrinolytics, anticoagulants and antiplatelet drugs increases risk of bleeding
- Profound thrombocytopenia reported; monitor platelet counts beginning about 6 hr after treatment initiation and daily thereafter
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (43)
- Abrocitinib + Tirofiban Major
- Acalabrutinib + Tirofiban Major
- Acetylsalicylic acid + Tirofiban Major
- Antithrombin alfa + Tirofiban Major
- Antithrombin iii + Tirofiban Major
- Apixaban + Tirofiban Major
- Argatroban + Tirofiban Major
- Betrixaban + Tirofiban Major
- Bivalirudin + Tirofiban Major
- Caplacizumab + Tirofiban Major
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Tirofiban used for?
Tirofiban is a medicine in the class cardiovascular. It is used for Acute coronary syndrome.
What side effects have been reported with Tirofiban?
Dizziness, Bradycardia, Bleeding, Pelvic pain, Coronary artery dissection, Lower extremity pain.
Can Tirofiban be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Case reports have not linked it to birth defects or other harm; no fetal harm in rats or rabbits at higher doses. Untreated heart attack can be fatal to mother and fetus. Bleeding is the main risk, especially near delivery. Use if clearly needed. Breastfeeding: Safe. No human milk data; present in rat milk. Given IV and poorly absorbed orally, so the infant is unlikely to absorb meaningful amounts. LactMed: not a reason to stop breastfeeding; watch the infant for bruising or bleeding.
What does Tirofiban interact with?
MediHelp lists 43 known interactions for Tirofiban. Major: 20 · Moderate: 13 · Minor: 10. The most serious include Abrocitinib, Acalabrutinib, Acetylsalicylic acid.
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