Riferimento farmaci
Zolbetuximab
Zolbetuximab is a medicine in the class oncology. It is used for gastric cancer.
- Classe del farmaco: Oncology
- Indicato per: gastric cancer
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Oncology
- Codice ATC
- L01FX31
- Forme farmaceutiche comuni
- iniezione
- Dosaggi comuni
- 20 mg/ml
- Nomi commerciali
- 2
- Paesi e mercati
- 2
Per cosa si usa
Come agisce
Claudin 18.2-directed cytolytic antibody that depletes CLDN18.2-positive cells via antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC).
Dose abituale nell'adulto (sintesi del foglio illustrativo)
HER2-negative, CLDN18.2-positive gastric/GEJ adenocarcinoma (with fluoropyrimidine- and platinum-containing chemotherapy): first dose 800 mg/m2 IV, then 600 mg/m2 IV every 3 weeks or 400 mg/m2 IV every 2 weeks; continue until disease progression or unacceptable toxicity
Gravidanza e allattamento
- Gravidanza
- Unknown No human data. No embryo-fetal toxicity in mice at about 1.9 times human exposure, though it crossed the placenta. Labels: give only if the benefit outweighs the potential risk. It is given with fluoropyrimidine and platinum chemotherapy, which can harm the fetus.
- Allattamento
- Unsafe No milk data; as a large antibody little is expected in milk (LactMed). Because of possible serious reactions in the infant, US label: do not breastfeed during treatment and for 8 months after the last dose; EU label: breastfeeding not recommended during treatment.
Effetti indesiderati segnalati
- Nausea
- Vomiting
- Fatigue
- Decreased appetite
- Diarrhea
- Peripheral sensory neuropathy
Chi deve prestare attenzione
- Hypersensitivity reactions including serious anaphylaxis and serious and fatal infusion-related reactions; monitor during and for at least 2 hours after infusion.
- Severe nausea and vomiting: VYLOY is emetogenic; premedicate with antiemetics before each infusion and manage with antiemetics or fluid replacement.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Altri farmaci della stessa classe
Domande frequenti
What is Zolbetuximab used for?
Zolbetuximab is a medicine in the class oncology. It is used for Gastric cancer.
What side effects have been reported with Zolbetuximab?
Nausea, Vomiting, Fatigue, Decreased appetite, Diarrhea, Peripheral sensory neuropathy.
Can Zolbetuximab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data. No embryo-fetal toxicity in mice at about 1.9 times human exposure, though it crossed the placenta. Labels: give only if the benefit outweighs the potential risk. It is given with fluoropyrimidine and platinum chemotherapy, which can harm the fetus. Breastfeeding: Unsafe. No milk data; as a large antibody little is expected in milk (LactMed). Because of possible serious reactions in the infant, US label: do not breastfeed during treatment and for 8 months after the last dose; EU label: breastfeeding not recommended during treatment.
What does Zolbetuximab interact with?
MediHelp does not list a checked interaction for Zolbetuximab yet. Always tell your pharmacist about every medicine you take.
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