Interazioni tra farmaci
Alfentanil + Codeine
Gravità: Maggiore
Alfentanil and Codeine: major interaction.
Ultimo aggiornamento
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Sintesi
Both are opioid agonists, so combined use increases sedation, respiratory depression and hypotension. The risk is highest with higher doses or in opioid-naive or elderly patients.
Cosa significa questa interazione in parole semplici
Alfentanil and Codeine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Additive mu-opioid receptor mediated CNS and respiratory depression.
Cosa fare
Avoid unplanned combinations; if used, lower doses and monitor respiratory rate and sedation closely. Ensure naloxone and ventilatory support are available in procedural settings.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Codeine
- Alvimopan + Codeine Controindicata
- Codeine + Isocarboxazid Controindicata
- Codeine + Olanzapine / samidorphan Controindicata
- Codeine + Phenelzine Controindicata
- Codeine + Tranylcypromine Controindicata
- Alprazolam + Codeine Maggiore
Domande frequenti
Can I take Alfentanil with Codeine?
MediHelp rates the interaction as major. Alfentanil and Codeine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are opioid agonists, so combined use increases sedation, respiratory depression and hypotension. The risk is highest with higher doses or in opioid-naive or elderly patients.
How serious is the interaction between Alfentanil and Codeine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unplanned combinations; if used, lower doses and monitor respiratory rate and sedation closely. Ensure naloxone and ventilatory support are available in procedural settings.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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