Interazioni tra farmaci
Codeine + Olanzapine / samidorphan
Gravità: Controindicata
Codeine and Olanzapine / samidorphan: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Samidorphan blocks opioid receptors, reducing codeine analgesia and potentially precipitating withdrawal in dependent patients. Higher opioid doses to override the blockade risk overdose.
Cosa significa questa interazione in parole semplici
Codeine and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Samidorphan is a mu-opioid receptor antagonist that opposes the effects of opioid agonists.
Cosa fare
Allow an opioid-free interval of at least 7 days before starting olanzapine/samidorphan. Choose a different antipsychotic if opioids are needed.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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- Additional notes
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Altre interazioni di Codeine
- Alvimopan + Codeine Controindicata
- Codeine + Isocarboxazid Controindicata
- Codeine + Phenelzine Controindicata
- Codeine + Tranylcypromine Controindicata
- Alfentanil + Codeine Maggiore
- Alprazolam + Codeine Maggiore
Domande frequenti
Can I take Codeine with Olanzapine / samidorphan?
MediHelp rates the interaction as contraindicated. Codeine and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan blocks opioid receptors, reducing codeine analgesia and potentially precipitating withdrawal in dependent patients. Higher opioid doses to override the blockade risk overdose.
How serious is the interaction between Codeine and Olanzapine / samidorphan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Allow an opioid-free interval of at least 7 days before starting olanzapine/samidorphan. Choose a different antipsychotic if opioids are needed.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Phenelzine. The full list is on the Codeine page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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