Interazioni tra farmaci
Alvimopan + Codeine
Gravità: Controindicata
Alvimopan and Codeine: contraindicated interaction.
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Sintesi
Alvimopan antagonises peripheral mu-opioid receptors, and patients who have taken opioids for more than 7 days can have exaggerated gastrointestinal effects including pain, nausea, vomiting and diarrhea. Short-term perioperative opioid use is not expected to be problematic.
Cosa significa questa interazione in parole semplici
Alvimopan and Codeine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Competitive antagonism of peripheral mu-opioid receptors by alvimopan.
Cosa fare
Do not use alvimopan in patients with therapeutic opioid use for more than 7 consecutive days before starting it. Short-term opioid exposure does not require avoidance.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Codeine
- Codeine + Isocarboxazid Controindicata
- Codeine + Olanzapine / samidorphan Controindicata
- Codeine + Phenelzine Controindicata
- Codeine + Tranylcypromine Controindicata
- Alfentanil + Codeine Maggiore
- Alprazolam + Codeine Maggiore
Domande frequenti
Can I take Alvimopan with Codeine?
MediHelp rates the interaction as contraindicated. Alvimopan and Codeine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Alvimopan antagonises peripheral mu-opioid receptors, and patients who have taken opioids for more than 7 days can have exaggerated gastrointestinal effects including pain, nausea, vomiting and diarrhea. Short-term perioperative opioid use is not expected to be problematic.
How serious is the interaction between Alvimopan and Codeine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use alvimopan in patients with therapeutic opioid use for more than 7 consecutive days before starting it. Short-term opioid exposure does not require avoidance.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Codeine page.
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