Interazioni tra farmaci
Codeine + Tranylcypromine
Gravità: Controindicata
Codeine and Tranylcypromine: contraindicated interaction.
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Sintesi
Tranylcypromine, a nonselective MAOI, combined with codeine can cause serotonin syndrome or an opioid-MAOI reaction with hyperthermia, blood pressure instability, coma and respiratory depression, which may be fatal.
Cosa significa questa interazione in parole semplici
Codeine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Codeine belongs to Musculoskeletal; Tranylcypromine belongs to Central Nervous System.
Perché avviene
Irreversible MAO inhibition combined with opioid serotonergic and CNS depressant effects.
Cosa fare
Do not use codeine during or within 14 days of stopping tranylcypromine. Use a non-serotonergic analgesic.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Codeine
- Alvimopan + Codeine Controindicata
- Codeine + Isocarboxazid Controindicata
- Codeine + Olanzapine / samidorphan Controindicata
- Codeine + Phenelzine Controindicata
- Alfentanil + Codeine Maggiore
- Alprazolam + Codeine Maggiore
Altre interazioni di Tranylcypromine
- 5-HTP + Tranylcypromine Controindicata
- Amitriptyline + Tranylcypromine Controindicata
- Amoxapine + Tranylcypromine Controindicata
- Atomoxetine + Tranylcypromine Controindicata
- Benzphetamine + Tranylcypromine Controindicata
- Brimonidine + Tranylcypromine Controindicata
Domande frequenti
Can I take Codeine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Codeine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tranylcypromine, a nonselective MAOI, combined with codeine can cause serotonin syndrome or an opioid-MAOI reaction with hyperthermia, blood pressure instability, coma and respiratory depression, which may be fatal.
How serious is the interaction between Codeine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use codeine during or within 14 days of stopping tranylcypromine. Use a non-serotonergic analgesic.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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