Interazioni tra farmaci
Alfentanil + Morphine
Gravità: Maggiore
Alfentanil and Morphine: major interaction.
Ultimo aggiornamento
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Sintesi
Combining two opioids adds to sedation, respiratory depression and hypotension. The risk is highest during dose changes, in opioid-naive patients and in the elderly.
Cosa significa questa interazione in parole semplici
Alfentanil and Morphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Additive mu-opioid receptor mediated CNS and respiratory depression.
Cosa fare
Use the lowest effective doses with continuous respiratory and sedation monitoring. Have naloxone available.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Morphine
- Alvimopan + Morphine Controindicata
- Isocarboxazid + Morphine Controindicata
- Morphine + Olanzapine / samidorphan Controindicata
- Morphine + Phenelzine Controindicata
- Morphine + Tranylcypromine Controindicata
- Alprazolam + Morphine Maggiore
Domande frequenti
Can I take Alfentanil with Morphine?
MediHelp rates the interaction as major. Alfentanil and Morphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two opioids adds to sedation, respiratory depression and hypotension. The risk is highest during dose changes, in opioid-naive patients and in the elderly.
How serious is the interaction between Alfentanil and Morphine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses with continuous respiratory and sedation monitoring. Have naloxone available.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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