Interazioni tra farmaci
Morphine + Olanzapine / samidorphan
Gravità: Controindicata
Morphine and Olanzapine / samidorphan: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Samidorphan is an opioid antagonist that blocks morphine's effect and can precipitate acute withdrawal in opioid-dependent patients. Patients on opioids who start the combination may also have reduced analgesia.
Cosa significa questa interazione in parole semplici
Morphine and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Pharmacodynamic antagonism at opioid receptors by samidorphan.
Cosa fare
Do not start in patients using opioids; ensure an opioid-free interval of at least 7 days for short-acting opioids before starting. Use an alternative antipsychotic if opioids are required.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Morphine
- Alvimopan + Morphine Controindicata
- Isocarboxazid + Morphine Controindicata
- Morphine + Phenelzine Controindicata
- Morphine + Tranylcypromine Controindicata
- Alfentanil + Morphine Maggiore
- Alprazolam + Morphine Maggiore
Domande frequenti
Can I take Morphine with Olanzapine / samidorphan?
MediHelp rates the interaction as contraindicated. Morphine and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan is an opioid antagonist that blocks morphine's effect and can precipitate acute withdrawal in opioid-dependent patients. Patients on opioids who start the combination may also have reduced analgesia.
How serious is the interaction between Morphine and Olanzapine / samidorphan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not start in patients using opioids; ensure an opioid-free interval of at least 7 days for short-acting opioids before starting. Use an alternative antipsychotic if opioids are required.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Phenelzine. The full list is on the Morphine page.
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