Interazioni tra farmaci
Isocarboxazid + Morphine
Gravità: Controindicata
Isocarboxazid and Morphine: contraindicated interaction.
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Sintesi
Opioids given with MAO inhibitors can cause severe reactions, including serotonin syndrome-like excitation, hyperpyrexia, hypertension or hypotension, and coma. Labeling of nonselective MAOIs advises against co-use with opioids.
Cosa significa questa interazione in parole semplici
Isocarboxazid and Morphine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Perché avviene
Nonselective MAO inhibition combined with opioid effects leads to serotonergic toxicity and unpredictable CNS and cardiovascular responses.
Cosa fare
Avoid concurrent use and allow about 14 days after stopping isocarboxazid before giving morphine where possible. Use a non-opioid alternative, and if an opioid is unavoidable, monitor intensively.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Morphine
- Alvimopan + Morphine Controindicata
- Morphine + Olanzapine / samidorphan Controindicata
- Morphine + Phenelzine Controindicata
- Morphine + Tranylcypromine Controindicata
- Alfentanil + Morphine Maggiore
- Alprazolam + Morphine Maggiore
Altre interazioni di Isocarboxazid
- 5-HTP + Isocarboxazid Controindicata
- Amitriptyline + Isocarboxazid Controindicata
- Amobarbital + Isocarboxazid Controindicata
- Amoxapine + Isocarboxazid Controindicata
- Apraclonidine + Isocarboxazid Controindicata
- Atomoxetine + Isocarboxazid Controindicata
Domande frequenti
Can I take Isocarboxazid with Morphine?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Morphine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids given with MAO inhibitors can cause severe reactions, including serotonin syndrome-like excitation, hyperpyrexia, hypertension or hypotension, and coma. Labeling of nonselective MAOIs advises against co-use with opioids.
How serious is the interaction between Isocarboxazid and Morphine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and allow about 14 days after stopping isocarboxazid before giving morphine where possible. Use a non-opioid alternative, and if an opioid is unavoidable, monitor intensively.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Olanzapine / samidorphan, Phenelzine. The full list is on the Morphine page.
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