Interazioni tra farmaci
Morphine + Tranylcypromine
Gravità: Controindicata
Morphine and Tranylcypromine: contraindicated interaction.
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Sintesi
Opioids with non-selective MAO inhibitors may cause serotonin syndrome or severe CNS depression, hypotension and hyperpyrexia. Morphine labeling advises against its use with MAOIs or within 14 days of stopping them.
Cosa significa questa interazione in parole semplici
Morphine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Morphine belongs to Musculoskeletal; Tranylcypromine belongs to Central Nervous System.
Perché avviene
Irreversible MAO inhibition potentiates serotonergic and CNS depressant effects of the opioid.
Cosa fare
Avoid morphine during tranylcypromine therapy and for 14 days afterward; use non-opioid alternatives. If unavoidable, give under close specialist monitoring.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Morphine
- Alvimopan + Morphine Controindicata
- Isocarboxazid + Morphine Controindicata
- Morphine + Olanzapine / samidorphan Controindicata
- Morphine + Phenelzine Controindicata
- Alfentanil + Morphine Maggiore
- Alprazolam + Morphine Maggiore
Altre interazioni di Tranylcypromine
- 5-HTP + Tranylcypromine Controindicata
- Amitriptyline + Tranylcypromine Controindicata
- Amoxapine + Tranylcypromine Controindicata
- Atomoxetine + Tranylcypromine Controindicata
- Benzphetamine + Tranylcypromine Controindicata
- Brimonidine + Tranylcypromine Controindicata
Domande frequenti
Can I take Morphine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Morphine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids with non-selective MAO inhibitors may cause serotonin syndrome or severe CNS depression, hypotension and hyperpyrexia. Morphine labeling advises against its use with MAOIs or within 14 days of stopping them.
How serious is the interaction between Morphine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid morphine during tranylcypromine therapy and for 14 days afterward; use non-opioid alternatives. If unavoidable, give under close specialist monitoring.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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