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Interazioni tra farmaci

Almotriptan + Ergotamine

Gravità: Controindicata

Almotriptan and Ergotamine: contraindicated interaction.

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Sintesi

Ergotamine and almotriptan both constrict vascular smooth muscle through serotonin receptors. Used in close succession they can cause sustained vasospasm with cerebral or limb ischaemia.

Cosa significa questa interazione in parole semplici

Almotriptan and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Almotriptan belongs to Central Nervous System; Ergotamine belongs to Central Nervous System.

Livello di evidenza: High

Perché avviene

Additive vasoconstriction (5-HT1B/1D agonism)

Cosa fare

Separate the two by at least 24 hours or choose a single agent.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Almotriptan with Ergotamine?

MediHelp rates the interaction as contraindicated. Almotriptan and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ergotamine and almotriptan both constrict vascular smooth muscle through serotonin receptors. Used in close succession they can cause sustained vasospasm with cerebral or limb ischaemia.

How serious is the interaction between Almotriptan and Ergotamine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate the two by at least 24 hours or choose a single agent.

What other medicines interact with Almotriptan?

MediHelp also lists interactions of Almotriptan with, for example, Dihydroergotamine, Dihydroergotamine intranasal, Eletriptan. The full list is on the Almotriptan page.

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