Interazioni tra farmaci
Cobicistat + Ergotamine
Gravità: Controindicata
Cobicistat and Ergotamine: contraindicated interaction.
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Sintesi
Cobicistat strongly inhibits CYP3A4 and can sharply raise ergotamine concentrations. This can precipitate acute ergotism with severe peripheral vasospasm and ischemia of the limbs, brain or heart.
Cosa significa questa interazione in parole semplici
Cobicistat and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Ergotamine belongs to Central Nervous System.
Perché avviene
Inhibition of CYP3A4-mediated ergotamine metabolism.
Cosa fare
Do not co-administer. Use a non-ergot migraine therapy during treatment with cobicistat.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Ergotamine
- Almotriptan + Ergotamine Controindicata
- Atazanavir + Ergotamine Controindicata
- Clarithromycin + Ergotamine Controindicata
- Darunavir + Ergotamine Controindicata
- Dihydroergotamine intranasal + Ergotamine Controindicata
- Dihydroergotamine + Ergotamine Controindicata
Altre interazioni di Cobicistat
- Alfuzosin + Cobicistat Controindicata
- Apalutamide + Cobicistat Controindicata
- Cobicistat + Colchicine Controindicata
- Cobicistat + Dronedarone Controindicata
- Cobicistat + Eletriptan Controindicata
- Cobicistat + Eplerenone Controindicata
Domande frequenti
Can I take Cobicistat with Ergotamine?
MediHelp rates the interaction as contraindicated. Cobicistat and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat strongly inhibits CYP3A4 and can sharply raise ergotamine concentrations. This can precipitate acute ergotism with severe peripheral vasospasm and ischemia of the limbs, brain or heart.
How serious is the interaction between Cobicistat and Ergotamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use a non-ergot migraine therapy during treatment with cobicistat.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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