Interazioni tra farmaci
Clarithromycin + Ergotamine
Gravità: Controindicata
Clarithromycin and Ergotamine: contraindicated interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Clarithromycin increases ergotamine concentrations and has been associated with acute ergot toxicity, including severe vasospasm and ischemia of the extremities, central nervous system and heart. Serious ischemic complications have been reported, sometimes after only a few doses. Concomitant use is contraindicated in product labeling.
Cosa significa questa interazione in parole semplici
Clarithromycin and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Ergotamine belongs to Central Nervous System.
Perché avviene
Clarithromycin strongly inhibits CYP3A4, reducing the metabolism of ergotamine and causing excessive exposure and vasoconstriction.
Cosa fare
Do not combine; choose a non-interacting antibiotic such as azithromycin (weaker effect) or another class suited to the infection if an ergot is needed. Alternatively withhold ergotamine and treat migraine with a non-ergot agent while clarithromycin is given.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Riferimenti
Altre interazioni di Ergotamine
- Almotriptan + Ergotamine Controindicata
- Atazanavir + Ergotamine Controindicata
- Cobicistat + Ergotamine Controindicata
- Darunavir + Ergotamine Controindicata
- Dihydroergotamine intranasal + Ergotamine Controindicata
- Dihydroergotamine + Ergotamine Controindicata
Altre interazioni di Clarithromycin
- Astemizole + Clarithromycin Controindicata
- Avanafil + Clarithromycin Controindicata
- Cisapride + Clarithromycin Controindicata
- Clarithromycin + Colchicine Controindicata
- Clarithromycin + Conivaptan Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
Domande frequenti
Can I take Clarithromycin with Ergotamine?
MediHelp rates the interaction as contraindicated. Clarithromycin and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin increases ergotamine concentrations and has been associated with acute ergot toxicity, including severe vasospasm and ischemia of the extremities, central nervous system and heart. Serious ischemic complications have been reported, sometimes after only a few doses. Concomitant use is contraindicated in product labeling.
How serious is the interaction between Clarithromycin and Ergotamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose a non-interacting antibiotic such as azithromycin (weaker effect) or another class suited to the infection if an ergot is needed. Alternatively withhold ergotamine and treat migraine with a non-ergot agent while clarithromycin is given.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Cobicistat. The full list is on the Ergotamine page.
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