Interazioni tra farmaci
Amlodipine-benazepril + Bismuth subsalicylate
Gravità: Moderata
Amlodipine-benazepril and Bismuth subsalicylate: moderate interaction.
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Sintesi
Bismuth subsalicylate releases salicylate, which can blunt the antihypertensive effect of benazepril and may add to renal risk. The effect is mainly relevant with frequent or prolonged use, or in dehydrated or renally impaired patients.
Cosa significa questa interazione in parole semplici
Amlodipine-benazepril and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Bismuth subsalicylate belongs to Gastrointestinal Tract.
Perché avviene
Salicylate inhibits prostaglandin synthesis, reducing renal vasodilation and sodium excretion and opposing ACE inhibitor effects.
Cosa fare
Limit bismuth subsalicylate to short-term use and avoid it in renal impairment or dehydration. Monitor blood pressure and renal function if use is prolonged.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Controindicata
- Amlodipine-benazepril + Sacubitril / valsartan Controindicata
- Aldesleukin + Amlodipine-benazepril Maggiore
- Amifostine + Amlodipine-benazepril Maggiore
- Amiloride + Amlodipine-benazepril Maggiore
- Amlodipine-benazepril + Azilsartan Maggiore
Altre interazioni di Bismuth subsalicylate
- Bismuth subsalicylate + Dichlorphenamide Maggiore
- Bismuth subsalicylate + Warfarin Maggiore
- Acetylsalicylic acid + Bismuth subsalicylate Moderata
- Aspirin / citric acid / sodium bicarbonate + Bismuth subsalicylate Moderata
- Aspirin rectal + Bismuth subsalicylate Moderata
- Aspirin + Bismuth subsalicylate Moderata
Domande frequenti
Can I take Amlodipine-benazepril with Bismuth subsalicylate?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bismuth subsalicylate releases salicylate, which can blunt the antihypertensive effect of benazepril and may add to renal risk. The effect is mainly relevant with frequent or prolonged use, or in dehydrated or renally impaired patients.
How serious is the interaction between Amlodipine-benazepril and Bismuth subsalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit bismuth subsalicylate to short-term use and avoid it in renal impairment or dehydration. Monitor blood pressure and renal function if use is prolonged.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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