Interazioni tra farmaci
Bismuth subsalicylate + Dichlorphenamide
Gravità: Maggiore
Bismuth subsalicylate and Dichlorphenamide: major interaction.
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Sintesi
Bismuth subsalicylate is hydrolysed to salicylate, and dichlorphenamide is a carbonic anhydrase inhibitor; with salicylates it can accumulate salicylate and worsen metabolic acidosis. Tachypnoea, lethargy and coma have been reported with high-dose aspirin.
Cosa significa questa interazione in parole semplici
Bismuth subsalicylate and Dichlorphenamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bismuth subsalicylate belongs to Gastrointestinal Tract; Dichlorphenamide belongs to Miscellaneous.
Perché avviene
Carbonic anhydrase inhibition causes metabolic acidosis and reduced salicylate renal clearance, raising salicylate levels
Cosa fare
Avoid bismuth subsalicylate during dichlorphenamide therapy; if salicylate is needed use lowest dose and monitor acid-base status and symptoms of salicylism.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Bismuth subsalicylate
- Bismuth subsalicylate + Warfarin Maggiore
- Acetylsalicylic acid + Bismuth subsalicylate Moderata
- Amlodipine-benazepril + Bismuth subsalicylate Moderata
- Aspirin / citric acid / sodium bicarbonate + Bismuth subsalicylate Moderata
- Aspirin rectal + Bismuth subsalicylate Moderata
- Aspirin + Bismuth subsalicylate Moderata
Altre interazioni di Dichlorphenamide
- Acetazolamide + Dichlorphenamide Maggiore
- Acetylsalicylic acid + Dichlorphenamide Maggiore
- Ammonium chloride + Dichlorphenamide Maggiore
- Aspirin rectal + Dichlorphenamide Maggiore
- Aspirin + Dichlorphenamide Maggiore
- Canagliflozin-metformin + Dichlorphenamide Maggiore
Domande frequenti
Can I take Bismuth subsalicylate with Dichlorphenamide?
MediHelp rates the interaction as major. Bismuth subsalicylate and Dichlorphenamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bismuth subsalicylate is hydrolysed to salicylate, and dichlorphenamide is a carbonic anhydrase inhibitor; with salicylates it can accumulate salicylate and worsen metabolic acidosis. Tachypnoea, lethargy and coma have been reported with high-dose aspirin.
How serious is the interaction between Bismuth subsalicylate and Dichlorphenamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid bismuth subsalicylate during dichlorphenamide therapy; if salicylate is needed use lowest dose and monitor acid-base status and symptoms of salicylism.
What other medicines interact with Bismuth subsalicylate?
MediHelp also lists interactions of Bismuth subsalicylate with, for example, Warfarin, Acetylsalicylic acid, Amlodipine-benazepril. The full list is on the Bismuth subsalicylate page.
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